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A00-280 - Clinical Trials Programming Using SAS 9 - Dump Information

Vendor	:	SASInstitute
Exam Code	:	A00-280
Exam Name	:	Clinical Trials Programming Using SAS 9
Questions and Answers	:	99 Q & A
Updated On	:	November 9, 2017
PDF Download Mirror	:	A00-280 Brain Dump
Get Full Version	:	Pass4sure A00-280 Full Version

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A00-280 Questions and Answers

QUESTION: 92

A Statistical Analysis Plan (SAP) defines the selection process for baseline records. This instructs the programmer to choose the last non-missing analyte value prior to first study drug administration (date/time). The DEMO data set contains the date/time of first study drug administration for subject:

What will be the resulting baseline values, as selected per the SAP instructions?

1. Option A
2. Option B
3. Option C
4. Option D

Answer: D

QUESTION: 93

From the Statistical Analysis Plan, patients age is calculated as an integer relative to date randomized divided by 365.25. Given the following annotated CRF:

Which programming code defines the patient's age?

1. age = int((birthdt-randdt)/365.25);
2. age = int((randdt-birthdt)/365.25);
3. age= int(yrdif(birthdt,randdt, "act/365.25" ));
4. age = int((today()-birthdt)/365.25);

Answer: B

QUESTION: 94

An action plan that describes what will be done in a drug study, how it will be conducted, and why each part of the study is necessary is called:

1. a clinical trial plan
2. a protocol
3. a data management plan
4. a statistical analysis plan

Answer: B

QUESTION: 95

What is the main focus of 21 CFR Part 11?

1. electronic submission requirements
2. trial safety requirements
   
   
3. statistical calculation requirements
4. trial protocol requirements

Answer: A

QUESTION: 96

What is an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects?

1. 21 CFR Part 11
2. Good Clinical Practices
3. MedDRA
4. WHODrug

Answer: B

QUESTION: 97

A patient received at least one dose of study medication prior to withdrawing from a study. Which analysis population would always include this patient?

1. efficacy
2. intent to treat
3. per protocol
4. safety

Answer: D

QUESTION: 98

A Statistical Analysis Plan describes a clinical trial as "A 12 week, double-blind, placebo- controlled, randomized, multi-center study." Double-blind refers to which groups in this study?

1. treatment and control group
2. investigator and subjects
3. statistician and sponsor
4. sponsor and investigator

Answer: B

QUESTION: 99

Given the following SAS program:

Which statement correctly identifies invalid values in the variable TRT, if only the values 'A', B', 'C are valid?

1. if indexc(TRT, 'ABC') eq 0 then output;
2. if index(TRT, 'ABC') eq 0 then output;
3. if find(TRT, 'ABC') eq 0 then output;
4. if indexw(TRT, 'ABC') eq 0 then output;

Answer: A

SASInstitute A00-280 Exam (Clinical Trials Programming Using SAS 9) Detailed Information

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Reporting capabilities SP2 Hotfix i admire to maintain my eye on the MS Downloads RSS feed and noticed this one coming through nowadays. if you feel you may need the hotfix which you could discover it right here. I have not had an opportunity to make use of SP2 in creation yet, so I haven't come throughout any of these concerns first hand, but from their descriptions i will be able to see why Microsoft has released a public hot repair instead of looking ahead to SP3.
This software patch contains fixes for right here concerns:

HTML Viewer style Sheet Configuration Property missing from provider Pack 2

incorrect line breaking or random formatting considerations with MHTML

Leaving and returning to the time table web page from the Subscription homes web page reasons based report parameters to be disabled, then reset to the primary or default price

Tables exported to CSV may also lose the first row of records

answer to Little Puzzlers–Validate a Sudoku Board this is the way I went about the "Validate a Sudoku Board” problem. youngsters, bear in mind there are distinctive how to resolve this, so don't be concerned in case your answer has adaptations and it’s completely feasible there are more efficient techniques.
believe free to indicate your solution within the comments right here or within the original post, however please be respectful of others’ efforts.
My method This one is relatively straight-forward, your simple task is to be sure that the price of any given cellphone isn’t replicated in the telephone’s row, column, or “dice”.  The issue is how you go about this.  there's an area-productive way, however requires extra looping, or there's a technique that requires best touring any cell one time, however requires further house.
on the grounds that the puzzle is fixed in dimension (9x9 grid), I’ll opt for improved algorithmic complexity and use area to grasp the set of all numbers seen for each and every given row, column, and cube.  through the use of 27 sets to cling these values (9 for the rows, 9 for the columns, 9 for the cubes), we can effortlessly see if we’ve alread A00-280y seen the latest quantity in the given row, column, or cube and immediately declare the puzzle invalid.
Of direction, we might get even more space-efficient and use 27 BitArrays (or one big one partitioned, and so on.), however then we lose the class of set good judgment.  i like maintaining issues logically simple after which optimizing for house after determining there's a necessity, so I’d probably opt to make use of units in my normal reply in an contrast, after which point out that if space were a priority, i would then optimize to BitArray.
So, here’s my solution:
1: public type SudokuBoard 2: three: inner most read A00-280only char[,] board; four: 5: // validate board is a 9x9 array 6: public SudokuBoard(char[,] board) 7: board.GetLength(0) != 9 15: 16: public bool Validate() 17: 18: // yes, i could use BitArray for house efficiency, however i admire the logical suppose 19: // of the set and the way it returns false on Add() if alread A00-280y there. 20: var rows = Enumerable.latitude(1, 9).opt for(i => new HashSet<char>()).ToArray(); 21: var columns = Enumerable.range(1, 9).select(i => new HashSet<char>()).ToArray(); 22: var cubes = Enumerable.range(1, 9).opt for(i => new HashSet<char>()).ToArray(); 23: 24: // method every mobile best once 25: for (int row = 0; row < 9; ++row) 26: 27: for (int column = 0; column < 9; ++column) 28: 29: var current = board[row, column]; 30: if (char.IsDigit(existing)) 31: 41: 42: forty three: 44: return true; 45: forty six: be aware that I’m not checking for invalid characters for the sake of brevity, although we could simply try this in the constructor, or in the Validate() method itself:
1: var current = board[row, column]; 2: if (char.IsDigit(latest)) three: four: // blah blah blah 5: 6: else if (!char.IsWhiteSpace(latest)) 7: eight: return false; 9: at last, here’s a simple driver to illustrate utilization:
1: public static category Driver 2: three: public static void function() four: 5: var board = new char[9,9] 6: 7: '5', '3', ' ', ' ', '7', ' ', ' ', ' ', ' ', 8: '6', ' ', ' ', '1', '9', '5', ' ', ' ', ' ', 9: ' ', '9', 'eight', ' ', ' ', ' ', ' ', '6', ' ', 10: '8', ' ', '2', ' ', '6', ' ', ' ', ' ', 'three', 11: '4', ' ', ' ', 'eight', ' ', '3', ' ', ' ', '1', 12: '7', ' ', ' ', ' ', '2', ' ', ' ', ' ', '6', 13: ' ', '6', ' ', ' ', ' ', ' ', '2', '8', ' ', 14: ' ', ' ', ' ', 'four', '1', '9', ' ', ' ', '5', 15: ' ', ' ', ' ', ' ', 'eight', ' ', ' ', '7', '9', 16: ; 17: 18: var validator = new SudokuBoard(board); 19: 20: Console.WriteLine("The Sudoku board is " + (validator.Validate() ? "legitimate" : "invalid")); 21: 22: abstract Hope you had enjoyable with this one!  Of direction, I’m certain many obtainable can tweak the answer for efficiency in a considerable number of methods – however you get the aspect.
Have an answer that labored for you but changed into absolutely different?  I’d like to hear about it!
reside tuned subsequent week for the next Little Puzzler.

SAS global Certification program choose an examination to peer the exam necessities for each: select an examination to look the entire content for every: clinical Trials Programming the use of SAS 9Clinical Trials Programming using SAS 9 – Accelerated version
exam subject matters consist of:

clinical Trials manner

Describe the scientific analysis method (phases, key roles, key organizations).

Interpret a Statistical analysis Plan.

Derive programming requirements from an SAP and an annotated Case document kind.

Describe regulatory requirements (principles of 21 CFR half 11, international convention on Harmonization, first rate scientific Practices).

medical Trials records constructions

identify the courses of clinical trials records (demographic, lab, baseline, concomitant medicine, etc.).

identify key CDISC principals and terms.

Describe the constitution and aim of the CDISC SDTM information model.

Describe the constitution and goal of the CDISC ADaM records model.

Describe the contents and goal of outline.xml.

Import and Export medical Trials records

combine SAS facts units.

successfully import and subset SAS information sets.

access facts in an Excel workbook (LIBNAME and PROC IMPORT/EXPORT).

Create temporary and permanent SAS information sets.

follow regulatory requirements to exported SAS records sets (SAS V5 necessities).

manipulate clinical Trials information

examine SAS records libraries the use of base SAS utility strategies (PRINT, CONTENTS, FREQ).

access DICTIONARY Tables using the SQL system.

sort observations in a SAS data set.

Create and regulate variable attributes the use of options and statements within the records step.

examine and discover clinical trials input facts (discover outliers, missing vs. zero values, and many others).

radically change medical Trials records

process records the use of DO LOOPS.

technique information the usage of SAS arrays.

maintain variables across observations.

Use task statements within the statistics step.

observe categorization and windowing recommendations to medical trials records.

Use SAS features to transform persona statistics to numeric and vice versa.

Use SAS functions to govern persona records, numeric data, and SAS date values.

Transpose SAS records sets.

practice 'observation elevate forward' suggestions to scientific trials statistics (LOCF, BOCF, WOCF).

Calculate 'trade from baseline' effects.

gain counts of hobbies in scientific trials.

observe Statistical approaches for scientific Trials

Use SAS tactics to obtain descriptive records for scientific trials statistics (FREQ, UNIVARIATE, capacity, abstract).

Use PROC FREQ to achieve p-values for specific information (2x2 and NxP test for association).

Use PROC TTEST to obtain p-values for continual statistics (one-pattern, paired and two-sample t-assessments).

Create output statistics sets from statistical strategies.

Macro Programming for clinical Trials

Create and use user-defined and automated macro variables.

Automate classes by means of defining and calling macros.

Use system options to debug macros and screen values of macro variables within the SAS log (MPRINT, SYMBOLGEN, MLOGIC, MACROGEN).

file clinical Trials results

Use PROC report to provide tables and listings for clinical trials reviews.

Use ODS and world statements to provide and augment clinical trials reports.

Validate scientific Trial information Reporting

clarify the concepts of programming validation within the medical trial business.

utilize the log file to validate clinical trial statistics reporting.

Use programming thoughts to validate medical trial facts reporting (PROC evaluate, MSGLEVEL).

determine and get to the bottom of statistics, syntax and common sense mistakes.

examination topics include:

scientific Trials technique

Describe the scientific research method (phases, key roles, key groups).

Interpret a Statistical evaluation Plan.

Derive programming necessities from an SAP and an annotated Case document form.

Describe regulatory requirements (concepts of 21 CFR part 11, international convention on Harmonization, good clinical Practices).

medical Trials records structures

establish the classes of medical trials statistics (demographic, lab, baseline, concomitant medicine, and so forth.).

establish key CDISC principals and phrases.

Describe the constitution and intention of the CDISC SDTM statistics mannequin.

Describe the constitution and aim of the CDISC ADaM records mannequin.

Describe the contents and aim of outline.xml.

Import and Export clinical Trials records

follow regulatory necessities to exported SAS records sets (SAS V5 requirements).

manipulate clinical Trials facts

access DICTIONARY Tables the use of the SQL procedure.

investigate and explore clinical trials enter information (locate outliers, lacking vs. zero values, and so on).

transform scientific Trials information

apply categorization and windowing concepts to clinical trials information.

Transpose SAS facts sets.

follow 'observation elevate forward' strategies to medical trials statistics (LOCF, BOCF, WOCF).

Calculate 'exchange from baseline' results.

reap counts of routine in scientific trials.

observe Statistical processes for clinical Trials

Use SAS techniques to acquire descriptive facts for clinical trials information (FREQ, UNIVARIATE, skill, abstract).

Use PROC FREQ to achieve p-values for categorical records (2x2 and NxP verify for association).

Use PROC TTEST to acquire p-values for continuous records (one-pattern, paired and two-pattern t-checks).

Create output facts units from statistical approaches.

Macro Programming for medical Trials

Create and use person-defined and automated macro variables.

Automate courses by defining and calling macros.

Use system alternatives to debug macros and monitor values of macro variables within the SAS log (MPRINT, SYMBOLGEN, MLOGIC, MACROGEN).

document clinical Trials effects

Use PROC document to supply tables and listings for clinical trials stories.

Use ODS and global statements to produce and augment clinical trials experiences.

Validate scientific Trial statistics Reporting

clarify the concepts of programming validation in the scientific trial trade.

make the most of the log file to validate clinical trial information reporting.

Use programming options to validate medical trial statistics reporting (PROC examine, MSGLEVEL).

establish and resolve information, syntax and logic error.

event is a important component to fitting a SAS certified knowledgeable. These resources are designed to help you prepare.These materials expect the candidate has little familiarity with SAS programming and the clinical trials business. depending on your level of experience, you may additionally no longer require all education components. for instance, a SAS certified Base Programmer would no longer require the Programming 1 and a pair of courses. Please review the exam objectives after which assess which substances will comprehensive your instruction.

* This credential is regarding medical trials programming. if your work is extra involving scientific information integration, please see the SAS medical information Integration: essentials direction.

working towards: Get training from SAS specialists. To view practising alternatives to your country, choose your area above. Books: White Papers, court cases, requisites follow: extra suggestions: Contact the SAS world Certification application at certification@sas.com or 800-727-0025. Registration alternate options: consult with Pearson VUE to register online. Candidates may no longer register directly at a Pearson VUE checking out facility. at the least 24 hours is required for registration for returning candidates. First-time candidates require further time.consult with www.pearsonvue.com/sas. observe these handy steps once on the web site:

attention first-time clients:You must "create" a new internet account inside Pearson VUE earlier than that you would be able to schedule a SAS exam. this may take in to 2 enterprise days in line with counsel supplied to provide your username and password crucial for examination registration. You will not have a SAS Candidate identity except after you have scheduled a SAS exam. It should be instantly assigned to you and despatched by the use of e-mail.

Returning users:if you have prior to now taken a SAS exam with Pearson VUE and created a web account, that you could use the "register" to register for an examination. if you don't be aware your sign-in tips, there are links inside Pearson VUE to support gain this assistance.

if you'd like assistance with registration, search for "need support? Contact customer provider" observed within the Pearson VUE registration web page a good way to give a listing of native numbers the place guide is available. checking out destinationsLocations for trying out may also be found at www.pearsonvue.com/sas beneath "discover a test region." all over registration, you're going to selected a vicinity to take your exam.SAS presents monthly examination sessions in Cary, NC and at some US conferences. For a SAS-subsidized US examination session, discuss with SAS-backed trying out activities in the US. For SAS-backed trying out backyard the USA, please contact your local SAS workplace.
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SAS presents a large number of IT certifications within the company intelligence area for IT execs working with records analytics, information mining, data warehousing, data administration, administration and greater.

What begun as an agricultural analysis assignment at North Carolina State tuition grew to become right into a full-fledged software and functions company via 1976. because its beginnings within the fields, as it have been, SAS has long past on to advance a superb customer base within the banking and pharmaceutical industries, in addition to in academia and at a large number of companies at all ranges of govt. today, SAS is a worldwide chief in enterprise analytics, information warehousing and records mining, with over four hundred offices in additional than 100 international locations. Its exact three competitors, in line with Hoover's Inc., are IBM, Oracle and SAP SE.
for the reason that the company's inception, SAS senior administration has fostered a culture that balances work and private existence, and encourages employees to take leadership positions, leading to consciousness yr after year as one of the vital superior locations to work by using groups akin to Fortune and the remarkable region to Work Institute. Coming in at number 4, SAS made its twelfth look in Fortune magazine's accurate 10 record of best companies to work for in 2015. The enterprise's low turnover expense (below 5 % in 2015 in comparison to an industry general of 16 %) is a trademark of its commitment to its employees and, not directly, to its customers as well.
Of the right 100 Fortune world 500 companies, 91 are SAS shoppers. SAS consumers span the globe with more than eighty,000 circumstances installed in 148 countries.
SAS Certification software Overview SAS has awarded over 75,000 certifications since the software's introduction in 1999. The SAS global Certification software presently presents eleven credentials across 5 categories:

basis equipment

advanced Analytics

business Intelligence and Analytics

facts management

Administration

SAS certifications, together with the required assessments and exam prices, are described in more details in here sections. youngsters experience degrees don't seem to be mainly indicated for each and every certification, a superb rule of thumb is at least eight months of experience on the bottom SAS system for Base Programmers and two to a few years of important, hands-on adventure for all different certifications before trying the exams. All tests are administered by using Pearson VUE or a SAS-backed certification examination session (typically along side working towards lessons).
Why Get SAS licensed? a quick search for "SAS programmer" on principal job posting sites will return tons of, if no longer thousands of open positions across the us, most with beginning salaries in a range from $70,000 to $a hundred and ten,000 USD. extra specialized certifications, exceptionally these involving facts and modeling, can force the annual earnings to over $one hundred thirty,000.
Suffice it to claim, a SAS certification pays off immediately. Couple that with a fine enterprise subculture, reaching a SAS credential and working for SAS is a sensible career circulation for any person with programming chops and a desire for toughness with a single company.
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SAS basis tools Certifications The foundation equipment credentials are aimed at analysts, data managers, programmers and the like whose workdays revolve around writing and managing SAS courses. The scientific Trials Programmer credential is more specialized to programmers who generate scientific trial experiences. right here are short descriptions of SAS basis tools certifications:
Certification Required examination(s) exam can charge* SAS certified Base Programmer for SAS 9SAS Base Programming for SAS 9 examination (A00-211) $180 SAS licensed advanced Programmer for SAS 9SAS advanced Programming for SAS 9 examination (A00-212) • should possess SAS licensed Base Programmer for SAS 9 credential $one hundred eighty SAS licensed scientific Trials Programmer using SAS ninemedical Trials Programming the usage of SAS 9 examination (A00-280)ORClinical Trials Programming the usage of SAS 9 – Accelerated version exam (A00-281) • Requires the SAS certified Base Programmer for SAS 9 credential $a hundred and eighty every exam * SAS presents a 50 % discount on the can charge of tests to instructors, students, faculty and body of workers at schools and better schooling associations, in addition to to SAS personnel. See the SAS FAQ for particulars. SAS advanced Analytics Certifications The superior Analytics credentials are designed for technical analysts, statisticians, information scientists etc who acquire, manipulate and analyze big data using SAS equipment, run reports and make business innovations in accordance with advanced models. The certifications during this category include:
Certification Required exam(s) examination charge* SAS certified Predictive Modeler the usage of SAS commercial enterprise Miner 13 Predictive Modeling the usage of SAS business Miner 13 exam $250 SAS licensed Statistical enterprise Analyst the usage of SAS 9: Regression and Modeling SAS Statistical business analysis using SAS 9: Regression and Modeling exam (A00-240) $180 * SAS presents a 50 % discount on the charge of exams to instructors, college students, school and team of workers at schools and higher schooling associations, as well as to SAS personnel. See the SAS FAQ for particulars.
The SAS Certification web page suggests two new certifications could be attainable someday in 2016: one for records scientist and one other for advanced analytics. The SAS certified statistics Scientist using SAS 9 credential aims professionals who manipulate large information the use of open supply and SAS equipment, make suggestions and install in SAS environments. To gain the credential, candidates must earn each the SAS licensed massive data knowledgeable using SAS 9 and SAS certified advanced Analytics knowledgeable the use of SAS 9 credentials.
SAS licensed advanced Analytics professional the use of SAS 9 credential targets IT gurus the use of predictive modeling and statistical analysis to research massive records. To earn the credential, candidates will need to circulate three checks:  Predictive Modeling using SAS business Miner 13, SAS superior Predictive Modeling (A00-225) and SAS text Analytics, Time series, Experimentation and Optimization (A00-226).
SAS company Intelligence And Analytics Certifications The enterprise Intelligence and Analytics credentials are geared for content material builders and analysts who create interfaces and reviews for SAS 9 or who use SAS visual Analytics automatically. There are two certifications during this category:

SAS certified BI content Developer for SAS 9: The BI content Developer focuses particularly on growing, implementing and customizing SAS interface applications (equivalent to reporting applications), together with records management and dashboard advent.

SAS certified visible enterprise Analyst: Exploration and Design using SAS visible Analytics: This credential pursuits analysts who use SAS visible Analytics, visual Analytics Explorer, and visual Analytics clothier to add, manipulate, and explore statistics, and create reports.

Certification Required exam(s) examination cost* SAS licensed BI content Developer for SAS nineSAS BI content material building for SAS 9 exam (A00-270) $a hundred and eighty SAS licensed visible business Analyst: Exploration and Design the usage of SAS visible Analytics SAS visible Analyst 7.3 Exploration and Design exam $a hundred and eighty * SAS offers a 50 p.c bargain on the can charge of checks to instructors, college students, school and group of workers at colleges and higher training associations, in addition to to SAS employees. See the SAS FAQ for details. SAS facts administration Certifications Analysts, programmers and statistics managers gravitate to statistics management credentials if their workdays (or career aspirations) revolve greater around managing facts and systems instead of deep facts, evaluation and modeling. the following describe certifications in this category:
Certification Required examination(s) exam cost* SAS certified massive facts professional the use of SAS nineSAS huge records guidance, information, and visible Exploration examination (A00-220)SAS big information Programming and Loading examination (A00-221) $180 eachSAS licensed statistics Integration Developer for SAS 9SAS data Integration construction for SAS 9 examination (A00-260) $a hundred and eighty SAS certified facts nice Steward for SAS nineSAS information fine using DataFlux statistics administration Studio exam (A00-262) $180 * SAS presents a 50 p.c cut price on the cost of checks to instructors, students, school and personnel at colleges and higher education institutions, as well as to SAS personnel. See the SAS FAQ for particulars. SAS Administration Certifications The Administration class has a single credential—the SAS licensed Platform Administrator for SAS 9—designed for gurus who are chargeable for assisting the SAS business Analytics platform, from installing through day-to-day preservation. This position should understand a way to installation folders, manipulate user bills, computer screen device performance, follow security concepts, operate backups and comprehensive other administrative projects.
Certification Required examination(s) examination can charge* SAS certified Platform Administrator for SAS nineSAS Platform Administration for SAS 9 exam (A00-250) $180 * SAS presents a 50 p.c discount on the cost of checks to instructors, college students, school and personnel at schools and higher training associations, as well as to SAS personnel. See the SAS FAQ for particulars.
SAS practising And supplies SAS presents links to SAS classroom and e-study A00-280ing courses, pattern examination questions and whole apply assessments. confer with the examination practise tab for each certification on the SAS Certification site. Candidates can purchase certification programs that consist of practising classes, preparation substances and exam vouchers with usual discounts of 35 to 40 percent. kit expenditures fluctuate, ranging from $2,650 to over $4,000 USD after discounts are utilized.
The SAS training and Books web web page gives hyperlinks to certification prep books, training lessons, e-study A00-280ing opportunities (SAS onDemand), and the SAS global educational program.
Many colleges and universities, comparable to Philadelphia university, Florida State college and the tuition of Missouri, to name simply just a few, additionally offer a SAS certificate program to their undergraduate and graduate students. if you're in (or considering of going to) faculty, and have an interest in SAS, try your alternatives.
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